Chempublish Journal

Antioxidant Effectiveness Test of Kapok Leaf Extract Moisturizer (Ceiba Pentandra (L.) Gaertn.) with DPPH Method

Afidatul Muadifah — 2024-06-30

Dry skin can often cause psychological discomfort. Moisturizer is a preparation that is used to improve dry skin. Kapok plant (Ceiba pentandra L. Gaertn) can be used as an active ingredient of moisturizer and can be used as a treatment, where the chemical content in kapok leaves are flavonoids, saponins, alkaloids, phenolic compounds, tannins and terpenoids as antioxidants. This study aims to determine the antioxidant activity of kapok leaf extract and moisturizer preparations with DPPH method using UV-Vis spectrophotometer, physical quality of preparations and antioxidant activity of moisturizer preparations using DPPH method. Kapok leaf extract was made in various concentrations, namely 20 ppm, 40 ppm and 60 ppm. The IC50 value of kapok leaf extract is 67.4007 ppm which has strong antioxidant activity. Then variations in the concentration of kapok leaf extract were put into the formulation of moisturizer preparations, the results of moisturizer preparations of kapok leaf extract and vitamin C met the requirements of the physical quality test. The moisturizer preparation was continued and tested for antioxidant activity using the DPPH method with ascorbic acid as a comparison. The results of the IC50 value on the kapuk leaf extract moisturizer preparation are 110.065 ppm which is classified as having moderate antioxidant activity and while the vitamin C moisturizer preparation is 9.8417 ppm which is classified as having very strong antioxidant activity.

Optimization of Liquid Fructose Sugar Production from Cassava Peel Waste using the Isomerization Process

Ratu Mayoreta Debora — 2024-06-30

Synthesis of Carboxymethyl Cellulose from Mangrove Nipah (Nypa fruticans) as Vitamin C Coating for Drug Delivery System

Delviani Delviani — 2024-06-30

Vitamin C is one of the substances needed by the human body which acts as an antioxidant that effectively overcomes the effects of free radicals that damage cells in the body, but vitamin C has properties that are easily oxidized so that innovation is needed to coat (encapsulate) vitamin C in the form of capsules as a drug delivery system. One polymer that can be used for vitamin C encapsulation is cellulose. The cellulose content can be found in the skin and nipah fruit and then synthesized into carboxymethyl cellulose as a vitamin C coating. The microencapsulation method was carried out by mixing 3 g of carrageenan-CMC mixture with variations in the ratio of 1:0; 1:0.5 and 1:1 (%b/b). The encapsulated small beads were made in 200 mL of 2M KCl-CaCl solution by extrusion technique. The microencapsulant was then drained and continued with the crosslinking stage using Glutaraldehyde (GA) 1%. In this in vitro oral simulation study, the encapsulation ratio that produced the best treatment with the highest percentage of drug solubility in the intestine was the ratio (1:0.5), followed by (1:1) and the smallest (1:0) with percentage values of 15.42; 14.06; and 1.67 percent, respectively.

Potential of Organometallic Complex Compounds as Anticancer Drugs: A Review

Zaliari Nafisa Ardhani — 2024-06-30

Cancer is one of the deadliest diseases in the world. Currently, there are various types of anticancer drugs that are used to treat cancer, but they still have various side effects that can interfere with the quality of life of patients. Organometallic complexes (OCOs) are chemical compounds consisting of metal atoms bonded to carbon atoms. OCOs have various potential to be used as anticancer drugs, including their ability to specifically target cancer cells, inhibit cancer cell growth, and reduce the side effects of other anticancer drugs. The mechanism of action of OCOs involves interactions with nucleophilic molecules within the cell, including DNA, RNA, and proteins, as well as the formation of additional platinum products. In this review, we will discuss organometallic compounds that can function as anticancer drugs, such as platinum, ruthenium, iron, carboplatin, and oxaliplatin, which have been shown to be effective in fighting cancer. We will also discuss the mechanism of action of these compounds in cancer cells and the types of cancer cells that can be treated with organometallic compounds.

Method The Influence of Self-Efficacy and Learning Independence of Students on Chemistry Learning Achievement: Case Study State of 10th Grade Senior High School in Public High School 15 Pekanbaru

Ayu Rahmawati — 2024-06-30

Self-efficacy and learning independence are important factors in improving chemistry learning achievement and these factors must be mastered by students. This study aims to determine the effect of self-efficacy and learning independence on chemistry learning achievement partially or simultaneously. This type of research is a survey-research with a quantitative approach. The data collection methods for this study are questionnaires and documentation. The self-efficacy and learning independence questionnaires used were 21 questions after being validated. The questionnaires were distributed to all samples of 119 students taken using the simple random sampling technique. Documentation was used to collect data on chemistry learning achievement scores. Data analysis used in this study was multiple linear regression analysis. The results of the study showed (1) There is a positive and significant effect of self-efficacy partially on chemistry learning achievement, (2) there is a positive and significant effect of learning independence on learning achievement, (3) There is a positive and significant effect between self-efficacy and learning independence simultaneously on chemistry learning achievement.