Potential of Organometallic Complex Compounds as Anticancer Drugs: A Review

Authors

  • Zaliari Nafisa Ardhani Department of Chemistry Education, Faculty of Education and Teacher Training, Universitas Palangka Raya
  • Marvin Horale Pasaribu Department of Chemistry, Faculty of Mathematics and Science, Universitas Palangka Raya
  • Risky Prisnanda Department of Chemistry Education, Faculty of Education and Teacher Training, Universitas Palangka Raya, Palangka Raya 74874, Central Kalimantan, Indonesia
  • Maya Erliza Anggraeni Department of Chemistry Education, Faculty of Education and Teacher Training, Universitas Palangka Raya, Palangka Raya 74874, Central Kalimantan, Indonesia
  • Rendy Muhamad Iqbal Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, Skudai 81310, Johor, Malaysia

DOI:

https://doi.org/10.22437/chp.v8i1.31409

Keywords:

Anticancer drugs, Organometallic compounds, Reaction mechanism

Abstract

Cancer is one of the deadliest diseases in the world. Currently, there are various types of anticancer drugs that are used to treat cancer, but they still have various side effects that can interfere with the quality of life of patients. Organometallic complexes (OCOs) are chemical compounds consisting of metal atoms bonded to carbon atoms. OCOs have various potential to be used as anticancer drugs, including their ability to specifically target cancer cells, inhibit cancer cell growth, and reduce the side effects of other anticancer drugs. The mechanism of action of OCOs involves interactions with nucleophilic molecules within the cell, including DNA, RNA, and proteins, as well as the formation of additional platinum products. In this review, we will discuss organometallic compounds that can function as anticancer drugs, such as platinum, ruthenium, iron, carboplatin, and oxaliplatin, which have been shown to be effective in fighting cancer. We will also discuss the mechanism of action of these compounds in cancer cells and the types of cancer cells that can be treated with organometallic compounds.

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Author Biographies

Risky Prisnanda, Department of Chemistry Education, Faculty of Education and Teacher Training, Universitas Palangka Raya, Palangka Raya 74874, Central Kalimantan, Indonesia

Department of Chemistry Education, Faculty of Education and Teacher Training, Universitas Palangka Raya, Palangka Raya 74874, Central Kalimantan, Indonesia

Maya Erliza Anggraeni, Department of Chemistry Education, Faculty of Education and Teacher Training, Universitas Palangka Raya, Palangka Raya 74874, Central Kalimantan, Indonesia

Department of Chemistry Education, Faculty of Education and Teacher Training, Universitas Palangka Raya, Palangka Raya 74874, Central Kalimantan, Indonesia

Rendy Muhamad Iqbal, Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, Skudai 81310, Johor, Malaysia

Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, Skudai 81310, Johor, Malaysia

Advanced Membrane Technology Research Center (AMTEC), Faculty of Chemical and Energy, Engineering, Universiti Teknologi Malaysia, Skudai 81310, Johor, Malaysia

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Published

2024-06-30

How to Cite

Ardhani, Z. N., Pasaribu, M. H., Prisnanda, R., Anggraeni, M. E. ., & Iqbal, R. M. (2024). Potential of Organometallic Complex Compounds as Anticancer Drugs: A Review. Chempublish Journal, 8(1), 29-41. https://doi.org/10.22437/chp.v8i1.31409

Issue

Vol. 8 No. 1 (2024): Chempublish Journal

Section

Articles