Synthesis of Carboxymethyl Cellulose from Mangrove Nipah (Nypa fruticans) as Vitamin C Coating for Drug Delivery System

Penulis

  • Delviani Delviani Department of Chemistry, Faculty of Science and Technology, Universitas Jambi, INDONESIA
  • Vioala Giary Rizkillah Maharani Department of Chemistry, Faculty of Science and Technology, Universitas Jambi, INDONESIA
  • Putri Nur Shadrina Department of Chemistry, Faculty of Science and Technology, Universitas Jambi, INDONESIA
  • Noha Ali College of Engineering,Department of chemical engineering,University of Abu Dhabi,UAE
  • Indra Lasmana Tarigan Department of Chemistry, Faculty of Science and Technology, Universitas Jambi, INDONESIA

DOI:

https://doi.org/10.22437/chp.v8i1.31722

Kata Kunci:

Carboxylmethyl Cellulose, Drug Delivery, Encapsulation, Vitamin C

Abstrak

Vitamin C is one of the substances needed by the human body which acts as an antioxidant that effectively overcomes the effects of free radicals that damage cells in the body, but vitamin C has properties that are easily oxidized so that innovation is needed to coat (encapsulate) vitamin C in the form of capsules as a drug delivery system. One polymer that can be used for vitamin C encapsulation is cellulose. The cellulose content can be found in the skin and nipah fruit and then synthesized into carboxymethyl cellulose as a vitamin C coating. The microencapsulation method was carried out by mixing 3 g of carrageenan-CMC mixture with variations in the ratio of 1:0; 1:0.5 and 1:1 (%b/b). The encapsulated small beads were made in 200 mL of 2M KCl-CaCl solution by extrusion technique. The microencapsulant was then drained and continued with the crosslinking stage using Glutaraldehyde (GA) 1%. In this in vitro oral simulation study, the encapsulation ratio that produced the best treatment with the highest percentage of drug solubility in the intestine was the ratio (1:0.5), followed by (1:1) and the smallest (1:0) with percentage values of 15.42; 14.06; and 1.67 percent, respectively.

Unduhan

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Biografi Penulis

Delviani Delviani, Department of Chemistry, Faculty of Science and Technology, Universitas Jambi, INDONESIA

Department of Chemistry, Faculty of Science and Technology, Universitas Jambi, INDONESIA

Vioala Giary Rizkillah Maharani, Department of Chemistry, Faculty of Science and Technology, Universitas Jambi, INDONESIA

Department of Chemistry, Faculty of Science and Technology, Universitas Jambi, INDONESIA

Putri Nur Shadrina, Department of Chemistry, Faculty of Science and Technology, Universitas Jambi, INDONESIA

Department of Chemistry, Faculty of Science and Technology, Universitas Jambi, INDONESIA

Noha Ali, College of Engineering,Department of chemical engineering,University of Abu Dhabi,UAE

College of Engineering,Department of chemical engineering,University of Abu Dhabi,UAE 

Indra Lasmana Tarigan, Department of Chemistry, Faculty of Science and Technology, Universitas Jambi, INDONESIA

Department of Chemistry, Faculty of Science and Technology, Universitas Jambi, INDONESIA

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Diterbitkan

2024-06-30

Cara Mengutip

Delviani, D., Maharani, V. G. R., Shadrina, P. N., Ali, N., & Tarigan, I. L. (2024). Synthesis of Carboxymethyl Cellulose from Mangrove Nipah (Nypa fruticans) as Vitamin C Coating for Drug Delivery System. Chempublish Journal, 8(1), 19-28. https://doi.org/10.22437/chp.v8i1.31722